Sialyl-lewis x
WebOct 12, 2015 · The three known selectins, L-, E- and P-selectins, constitute a family of calcium-dependent cell surface glycoproteins that play a critical role in inflammation, mainly via recognition of specific carbohydrate ligands, sialyl Lewis X (sLe X) and sialyl Lewis A (sLe A) [1,2].Structural features common to the selectins are the presence of five distinct … WebApr 8, 2024 · In addition, sialyl Lewis X and sialyl Lewis a are also known to be the ligands of selectins that are a family of cell-adhesion molecules expressed on endothelial cells, leukocytes and platelets.
Sialyl-lewis x
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WebOct 21, 2024 · The impact of glycosylation on cell behavior largely depends on the terminal portions of glycoconjugates. Examples of terminal structures include α2,3- and α2,6-linked sialic acids, polysialic acid, the AB0 blood group, and other fucosylated structures such as the sialyl Lewis x (sLe x) and the sialyl Lewis a (sLe a) antigens [1,2,3]. WebSialyl Lewis x, Sodium Salt. Synonym(s): Sialyl Lewis x, Sodium Salt. Empirical Formula (Hill Notation): C 31 H 51 N 2 NaO 23. CAS No.: 98603-84-0. Molecular Weight: 842.73. …
WebMay 31, 2024 · Background: Lewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are … WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the …
WebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage. WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the …
WebApr 15, 2006 · CLA defines a subset of human peripheral helper memory T cells and has long been used as a specific carbohydrate determinant in characterizing skin-homing helper memory T-cell populations. 5 The HECA-452 antibody defining CLA was shown to recognize the sialyl Lewis X (Le x) determinant, which is known as a typical carbohydrate ligand for ...
WebMay 19, 2024 · Increased expression and colocalization of sialyl Lewis glycans and CD44v6 in inflamed colonic mucosa. Previous studies have shown that the anti-glycan mAb GM35 binds to sLe a on CD44v6 expressed by inflamed epithelium and reduces PMN transepithelital migration (TEpM) (6, 7).However, the potential of sialylated Lewis glycans … imaging places canberraWebSialyl-Lewis X C31H52N2O23 CID 643990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... list of full service brokerage firmsSialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the … See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more list of full names in the philippinesWebJun 8, 2010 · For example, sialyl-Lewis x (sLe x) antigens are the ligands for selectins and are involved in the recruitment of leukocytes to lymphoid tissues and inflammation sites . Glycan structures depend on the cell type, developmental stage and cell differentiation, and are modified in many pathologic states including cancers. list of full time jobsWebformer of the sialyl Lewis x exists in aqueous solution [5, 7, 9, 12]. These conclusions are controversial with some experimental and molecular modelling data [15, list of full service brokersWebG. Kretzschmar is an academic researcher. The author has contributed to research in topic(s): Sialyl-Lewis X & Oligosaccharide. The author has an hindex of 1, co-authored 3 publication(s) receiving 60 citation(s). imaging ppp model with government pptWebJun 3, 2024 · We also provide evidence that P-selectin is a key molecule on the peritoneal mesothelium that mediates the binding through a unique sialyl-Lewis x (sLe x) containing … list of full sail university courses