Sialyl lewis-x
WebJun 8, 2010 · For example, sialyl-Lewis x (sLe x) antigens are the ligands for selectins and are involved in the recruitment of leukocytes to lymphoid tissues and inflammation sites . Glycan structures depend on the cell type, developmental stage and cell differentiation, and are modified in many pathologic states including cancers. Sialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The studies done on these individuals' red … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes" See more
Sialyl lewis-x
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WebIt also recognizes Sialyl Lewis X with long carbohydrate attachments (Sialyl Lewis X-i). These antigens are expressed on human granulocytes, monocytes, small subsets of lymphocytes, some fetal tissues such as the fetal stomach, fetal colon, and fetal intestine, and a variety of cancer tissues. WebAug 18, 2011 · The high density of sialyl-Lewis x antennae observed on the ZP N-glycans …
WebJan 1, 1995 · Ligand Recognition by E- and P-Selectin: Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids. The Journal of Organic Chemistry 1998 , 63 (15) , 5137-5143. Webformer of the sialyl Lewis x exists in aqueous solution [5, 7, 9, 12]. These conclusions are controversial with some experimental and molecular modelling data [15,
WebSialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. … WebSialyl-Lewis X C31H52N2O23 CID 643990 - structure, chemical names, physical and …
WebSialyl-Lewis X C31H52N2O23 CID 643990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
WebNov 4, 2024 · Trinchera, M., Aronica, A. & Dall’Olio, F. Selectin ligands sialyl-lewis a and sialyl-lewis x in gastrointestinal cancers. Biology 6 , 16 (2024). Article PubMed Central Google Scholar grassland and savanna climateWebSialyl-Lewis X. SLeX is a key recognition determinant for selectins that allow endothelial … grassland and marshWebApr 8, 2024 · In addition, sialyl Lewis X and sialyl Lewis a are also known to be the ligands of selectins that are a family of cell-adhesion molecules expressed on endothelial cells, leukocytes and platelets. chiwawa a poil courtWebAug 20, 2015 · Aberrant glycosylation in cancer frequently involves an increase in sialyl Lewis x (SLe x) and SLe a (Ref. 41) antigens, as well as an increase in terminal α2,6-sialylated structures, both in ... grassland alberta foodWebStructures of sialyl Lewis x (sLe x) and sialyl Lewis a (sLe a). Selectins bind to glycans with a terminal tetrasaccharide structure known as sialyl Lewis x/a. The core of the terminal tetrasaccharide is a disaccharide of galactose linked to N-acetylglucosamine (GlcNAc), either in α1,4 (sLe x) or α1,3 (sLe a) linkage. chi waver reviewsWebApr 1, 1995 · An efficient synthesis of sialyl Lewis X (sLex) glycolipid as a potent selectin blocker is described. 2-(Tetradecyl)hexadecanol which functions as an artificial ceramide, was glycosylated with phenyl … Expand. 4. Save. Alert. Synthesis of the 3'-C-carboxymethyl Lewis X derivative: A novel selectin blocker. grassland anchor chartWebJun 3, 2024 · We also provide evidence that P-selectin is a key molecule on the peritoneal … grassland and shrubs