Cthrc1 fibrosis
WebMay 18, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic … WebApr 21, 2024 · In humans with pulmonary fibrosis we and others have analyzed, CTHRC1 + fibroblasts emerged in pulmonary fibrosis associated with IPF and scleroderma, suggesting that there might be common ...
Cthrc1 fibrosis
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WebJan 11, 2024 · We demonstrated that CTHRC1 is a new regulator of liver fibrosis by modulating TGF-β signaling. Targeting CTHRC1 could be a promising therapeutic approach, which can suppress TGF-β signaling … WebAbstract Pulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore, identifying additional therapeutic modalities is required to improve outcome. ... collagen triple helix repeat containing 1 (CTHRC1), claudin 2 (CLDN2), latent transforming growth factor beta binding protein 2 (LTBP2) were proven to involve disease ...
WebNov 11, 2024 · Lung fibrosis also progressed rapidly in this subset of NR-COVID-19 patients, where the development of lung injury to a state that a lung transplant was required for survival took 119 days ... Transcript … WebSep 23, 2024 · CTHRC1 is a secreted protein involved in a variety of processes, including vascular remodeling, anti-fibrosis, metabolism, and carcinogenesis. ... Wu Q, Yang Q, Sun H. Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in systemic lupus erythematosus. Lupus. 2024;27(13) ...
WebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized … WebNational Center for Biotechnology Information
WebSep 25, 2024 · To determine whether cluster B can be identified in other models of cardiac fibrosis, we examined the presence of CTHRC1 + CFs in a model of chronic cardiac fibrosis generated by infusion of angiotensin …
WebCthrc1 −/− animals have decreased lung function following bleomycin-induced fibrosis The rise in hydroxyproline was somewhat reflected in the measures of lung compliance. Bleomycin injection decreased lung … incl for nestingWebDec 23, 2004 · Collagen triple helix repeat containing 1 (Cthrc1) was identified in a screen for differentially expressed sequences in balloon-injured versus normal arteries. Cthrc1 expression was not detectable in … incorporating a company in malaysiaWebNational Center for Biotechnology Information incorporating a company in michiganWebMar 1, 2013 · Fibrosis is the main complication of muscular dystrophies. We identified collagen triple helix repeat containing 1 (Cthrc1) in skeletal and cardiac muscles of mice, representing Duchenne and congenital muscle dystrophies (DMD and CMD, respectively), and dysferlinopathy. incl full formWebApr 10, 2024 · We recently reported that DT-109 administered orally to mice at 500 mg/kg/day potently reduced steatohepatitis and fibrosis induced by a high-fat, -fructose, and -cholesterol diet (NASH diet). 13 To determine optimal dosing, we evaluated the dose response of DT-109 during NASH. C57BL/6J mice were fed the NASH diet for 12 weeks … incorporating a company in ontarioWebDec 10, 2024 · Interpretation: We demonstrated that CTHRC1 is a new regulator of liver fibrosis by modulating TGF-β signaling. Targeting CTHRC1 could be a promising therapeutic approach, which can suppress TGF-β signaling and avoid the side effects caused by directly targeting TGF-β. CTHRC1 could also be a potential biomarker for … incl diseaseWebApr 21, 2024 · One subpopulation, characterized by expression of Cthrc1 (collagen triple helix repeat containing 1), emerges in fibrotic lungs and expresses the highest levels of … incl group noida